Career Development Award

Grant number: 519730 | Funding period: 2008 - 2011

Completed

Abstract

Dependent drug use is associated with a range of physical and mental health problems. However the process by which drug-related changes to the human brain influence behaviours important to remaining abstinent is poorly understood. The current proposal investigates the neural and behavioural effects of drug dependence on cognitive control - responsible for impulse control and decision making - previously implicated in drug dependence.

Related publications (9)

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Left anterior cingulate activity predicts intra-individual reaction time variability in healthy adults

BP Johnson, A Pinar, A Fornito, LS Nandam, R Hester, MA Bellgrove

2015-06-01

Within-subject, or intra-individual, variability in reaction time (RT) is increasingly recognised as an important indicator of the..

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Improving control over the impulse for reward: Sensitivity of harmful alcohol drinkers to delayed reward but not immediate punishment

S Rossiter, J Thompson, R Hester

2012-09-01

Background: Cognitive control dysfunction has been identified in dependent alcohol users and implicated in the transition from abu..

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Successful inhibitory control over an immediate reward is associated with attentional disengagement in visual processing areas

DA O'Connor, S Rossiter, M Yücel, DI Lubman, R Hester

2012-09-01

We examined the neural basis of the capacity to resist an immediately rewarding stimulus in order to obtain a larger delayed rewar..

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Neurochemical enhancement of conscious error awareness

R Hester, L Sanjay Nandam, RG O'Connell, J Wagner, M Strudwick, PJ Nathan, JB Mattingley, MA Bellgrove

2012-02-22

How the brain monitors ongoing behavior for performance errors is a central question of cognitive neuroscience. Diminished awarene..

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The Effects of Modafinil Treatment on Neuropsychological and Attentional Bias Performance During 7-Day Inpatient Withdrawal From Methamphetamine Dependence

R Hester, N Lee, A Pennay, S Nielsen, J Ferris

2010-12-01

The cognitive benefits of modafinil to patients undergoing 7-day inpatient withdrawal from methamphetamine (MA) dependence were ex..

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Punishing an error improves learning: The influence of punishment magnitude on error-related neural activity and subsequent learning

R Hester, K Murphy, FL Brown, AJ Skilleter

2010-11-17

Punishing an error to shape subsequent performance is a major tenet of individual and societal level behavioral interventions. Rec..

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The role of executive control in human drug addiction

R Hester, DI Lubman, M Yü cel

2010-01-01

Recent neurobiological models propose that executive control deficits play a critical role in the development and maintenance of d..

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Impaired error awareness and anterior cingulate cortex hypoactivity in chronic cannabis users

R Hester, L Nestor, H Garavan

2009-10-01

Drug abuse and other psychiatric conditions (eg, schizophrenia) have been associated with a diminished neural response to errors, ..

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Learning from errors: Error-related neural activity predicts improvements in future inhibitory control performance

R Hester, J Madeley, K Murphy, JB Mattingley

2009-06-03

Failure to adapt performance following an error is a debilitating symptom of many neurological and psychiatric conditions. Healthy..

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